Authors: DMYTRO BILYI, MYKHAILO RUBLENKO, LIUDMYLA KOVALOVA, DMYTRO SLIUSARENKO, LIUDMYLA HALUZINA, OLEKSANDR STOTSKYI, SERGEY MASLIKOV

Abstract: This study presents the results of the study of clinical and hemostasis predictors of mammary gland tumors in bitches, which allow to determine the risk groups for this disease. The highest incidence rates were found in German and Eastern European Shepherds (22.1%), Dachshunds (12.8%) and Yorkshire terriers (9.5%) when kept in private households: 97.1%, 96.3% and 97.3%, respectively. Significantly increases the likelihood of mammary gland cancer in excess body weight - by 30%-100%, in the case of mixed feeding - up to 39.3%, the use of hormonal contraceptives - by 50%-60%. Adverse prognosis correlates with an increase in the size, nature of the surface and the relationship with the surrounding tissues of the lesion, localization in 4th and 5th pairs of the mammary glands. Progression of the disease is accompanied by the development of hypercoagulable syndrome, which is characterized by an increase in fibrinogen and soluble fibrin due to activation of external and internal coagulation pathways, as evidenced by the prolongation of activated partial thromboplastin and prothrombin time. The results of the screening can be used for prevention and early diagnosis of the disease, as well as the development of promising treatment protocols.

Keywords: Dogs, neoplasms, mammary gland, coagulation potential, risk factors

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