Exact Test for Investigation of Hardy-Weinberg Equilibrium

Authors: BAHAR ÇITAK, TAHSİN KESİCİ

Abstract: The use of exact and \chi^2 goodness-of-fit tests to control the hypothesis that a sample represents the population in Hardy-Weinberg equilibrium are explained and compared with each other. These tests were applied for the loci with two, three and four alleles. The reliability of these tests depends on the sample size. The results showed that the exact and \chi^2 goodness-of-fit tests provided almost the same results if the sample size is considerably large. The exact test is, however, more reliable than the \chi^2 goodness-of-fit test when the sample size is small.

Keywords: Exact test, Hardy-Weinberg Equilibrium

Full Text: PDF