Impact of the Haberlea rhodopensis extract on the innate immune system and response in rabbits following KLH-hemocyanin immunization and cyclophosphamide treatment

Authors: SVETLANA GEORGIEVA, LILIAN SOTIROV, BORISLAV POPOV, TSVETOSLAV KOYNARSKI

Abstract: The aim of the present investigation was to study the impact of Haberlea rhodopensis extract on the innate immune response in rabbits. The complement and lysozyme activity, percent phagocytosis, and phagocytic index were studied. The analysis of the results showed that the treatment with Haberlea rhodopensis extract, cyclophosphamide, and KLH renders a remittent effect upon the classical pathway of activation of the complement system and the lysozyme concentration in the rabbit blood serum. These same factors have no direct effect on the phagocytic activity in the investigated animals. The obtained data show limited effect of Haberlea rhodopensis extract on rabbits’ natural immunity.

Keywords: Haberlea rhodopensis, cyclophosphamide, complement, lysozyme, phagocytic activity

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