Influence of Physical Exercise on Serum Apolipoprotein A-I Containing Lipoproteins

Authors: Metin YILDIRIMKAYA, Kurtuluş YILMAZ, Muhsin KONUK, Cumhur KILINÇ, Türker KUTLUAY

Abstract: High density lipoprotein(HDL) contains at least two types of lipoprotein particles which might have different physiologic roles: lipoprotein (Lp) A-I and Lp A-I: A-II. The influence of exercise on the response of serum apo A-I containing lipoprotein particles was investigated in 30 healthy young males after 10 weeks of physical training at a milittary base. 30 sedentary males matched for age, body mass index (BMI), nutrient intake and lipid values comprised the control group. Total cholesterol (TC), high density lipoprotein cholesterol (HDL-C), HDL2-C, HDL3-C, low density lipoprotein cholesterol (LDL-C), triglycerides (TG), apolipoprotein (apo) A-I, apo B, Lp A-I and Lp A-I: A-II were studied before and after the exercise program in both groups. The exercise group showed a significant increase in HDL-C, HDL2-C, Lp A-I (p<0.001), apo A-1 (p<0.01) and a significant decrease in LDL-C, TG (p<0.01), apo B (p<0.005) after the exercise program while TC, HDL3-C and Lp A-1: A-II levels were unchanged. No significant changes were noted in serum lipids and apo A-1 containing lipoprotein particles in control group. This study suggest that HDL elevation observed in exercise training is mainly due to the increase of Lp A-1.

Keywords: HDL, Lp A-I, Lp A-I: II, Exercise