In Vitro Testing for Genotoxicity of 4-CPA by Sister Chromatid Exchange in Human Lymphocyte Culture

Authors: HÜSEYİN BAĞCI, GÜLSEREN BAĞCI, İBRAHİM AÇIKBAŞ, GÖKSEMİN DEMİR

Abstract: Certain phenoxyacetate derivatives used as plant growth regulators act as plant hormones. 2,4-D dichlorophenoxyacetic acid and 4-chlorophenoxyacetic acid are widely used in vegetable growing, especially tomatoes, in our region. These phenoxyacetic acid compounds are a potential hazard for the environment. There are conflicting results and inconsistent data about these herbicides in the literature. This is the first report of genotoxicity of 4-CPA evaluated by sister chromatid exchange in human lymphocyte culture. No significant change was found in sister chromatid exchange frequency at the tested 4-CPA concentration.

Keywords: 4-CPA, Phenoxy herbicides, genotoxicity, sister chromatid exchange, tomato

Full Text: PDF