The Relationship Between Plasma Lipid Parameters, Fibrinogen and Lipid Peroxidation in Patients with Angina Pectoris and Acute Myocardial Infarction

Authors: Kader KÖSE, Pakize DOĞAN, Ali ÜNAL, Mustafa ÇETİN, Ahmet H. KÖKER

Abstract: Plasma fibrinogen (FBN), triglyceride (TG), total cholesterol (T. Chol), LDL Chol, HDL-chol and malondialdehyde (MDA, as an index of lipid peroxidation) levels were estimated in both patients with angina pectoris (AP) and acute mycordial infarction (AMI). Statistically significant large increases in plasma MDA, FBN, TG, LDL-chol levels and a significant decrease in HDL-chol levels were found in both patient groups in comparison with the controls (p>0.05: p<0.01 ). Plasma T. chol levels of patients with AMI were also found to be higher than those of controls (p<0.01). Although there was no significant difference in TG, T. Chol aI)d HDLchol levels between patient groups: plasma MDA, FBN, LDL-chol levels were significantly higher in AMI patients than those of AP patients (p<0.05: p<0.01). When regression analyses were performed, significant positive correlations between MDA-FBN, MDA- TG. MDA- T . chol, MDA- LDL-chol, FBN- TG, FBNT. chol, T. chol-LDL-chol and a negative correlation between TG-HDL-chol levels were found in both patient groups (p<0.05; p<0.01). The existence of positive correlations between MDA and FBN and lipid parameters, assumed among well-known risk factors, may be suggest the posibiility of lipid peroxide interference with other metabolic pathways; and therefore, lipid peroxidation may be an important factor in the development of various pathological events associated with myocardial ischemia and infarction.

Keywords: Lipid peroxidation, fibrinogen, lipid parameters, Angina pectoris, Acute Myocardial lnfarction.