Urease inhibitory potential of Zizyphus oxyphylla Edgew. extracts and isolated compounds

Authors: WAQAR AHMAD KALEEM, MUHAMMAD NISAR, Mughal QAYUM, MUHAMMAD ZIA-UL-HAQ, MUHAMMAD IQBAL CHOUDHARY, SEZAİ ERCİŞLİ

Abstract: To determine the urease inhibitory potential of extracts and isolated compounds from Zizyphus oxyphylla Edgew. Materials and methods: Methanolic extracts and subsequent fractions of Z. oxyphylla stem and 3 isolated compounds from the roots of Z. oxyphylla were obtained through column chromatography and subjected to in vitro urease inhibition. Results: Three fractions (n-hexane, ethyl acetate, and butanol fractions) showed good to excellent activity, while the chloroform fraction showed nonsignificant activity. Amongst the isolated compounds, oxyphylline D (1) was the most active of the 3 isolated cyclopeptide alkaloids, followed by nummularin R (3) and nummularin C (2). Conclusion: Z. oxyphylla has the potential to be used in the treatment of various complications produced by urease enzymes, such as gastric ulcers.

Keywords: Zizyphus oxyphylla, cyclopeptide alkaloids, urease

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