Plasma Fibrinogen Level Alterations in Patients Following Acute Myocardial Infarction

Authors: Kader KÖSE, Pakize DOĞAN, Ali ÜNAL, Ahmet H. KÖKER

Abstract: In order to evaluate whether fibrinogen (FBN) is increased following an infarction, we determined plasma FBN levels in patients with acute myocardial infarction (AMI), at initial presentation and also on sequential days 2, 3, 4 and 15 post-infarction. Control subjects were included in the study, with the same parameter being measured only once in them. Plasma FBN levels were found to be elevated in the AMI patients on each of the five days (3.89 g/L at initial presentation; 4.85 g/L on day 2; 5.90 g/L on day 3; 7.17 g/L on day 4; and 4.82 g/L on day 15) compared to the controls (2.88 g/L) (p<0.001). When the volues from different days in the patient group were compared to each other, a gradual increase was observed in the FBN levels. This was particularly significant on days 3 and 4 following infarction. however, the decreased level of FBN seen on the 15th day after the infarction, compared to the value measured on day 4, was found to be higher than the baseline level and similar to the level on the day of the infarction.

Keywords: Acute myocardial infarction, fibrinogen