The Effects of Vitamin E on Gastric Ulcers and Gastric Mucosal Barrier in Stress Induced Rats

Authors: Cihat GÜZEL, Doğan KURT, Abdurrahman SERMET, Zeki KANAY, Orhan DENLİ, Fikri CANORUÇ

Abstract: Effects of vitamin E on gastric ulcers gastric mucosal barrier were in-vestigated in cold + restraint stress (CRS) induced rats. In this study 21 males two month old Swiss Albino Rats were used. Stress treated rats significantly decreased mucus and phospholipid content of gastric mucosa (p<0.01, P<0.01). Vitamin E was administered orally in the dose of 100 mg/kg body weight thirty min. before stress. Vitamin E reduced significantly gastric ulceration (p<0.01). Moreover, it significanly protected mucus secretion and phospholipid content of gastric mucosa in rats (p<0.01, p<0.01, respectively). These results indicate that extrinsic application of vitamin E may strengthen gastric mucosal barrier in rats.

Keywords: Vitamin E, Stress, Gastric mucosal barrier.

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