The Serum Levels of Some Important Elements and Alkaline Phosphatase in Patients with Atopic Dermatitis

Authors: Vedat ERTUNÇ, Muammer PARLAK, Şenol DANE, Akın AKTAŞ, Ali KARAKUZU, İrfan ALTUNTAŞ

Abstract: Serum zinc, calcium, phosphorus, copper magnesium, iron, albumin and alkaline phosphatase (AP) levels were measured in 50 atopic dermatitis (AD) patients and 35 subjects. There was no statistically significant difference in serum zinc and magnesium levels between AD patients and controls. The serum copper, phosphorus, and calcium levels were significantly higher in patients than in controls. The serum iron and albumin levels were signicantly lower in patients than in controls. There was no correlation between severity scoring of atopic dermatitis (scorad) and serum zinc, iron, copper magnesium and albumin concentrations, but there was a positive linear correlation between scorad and the serum calcium and phosphorus levels. In addation, the relationship between serum zinc, copper, and magnesium levels and serum AP activity in AD patients was investigated. There was found to be a statistically significant difference in serum AP between AD patients and controls. There was a positive linear correlation between serum AP and zinc concentrations in AD patiens. There was no correlation between serum zinc and copper levels or between serum zinc and albumin concentrations. There was negative linear correlation between age and serum AP concentrations in patients. These findings suggest that serum alkaline phosphatase level may be a useful index in diagnosis of AD disease.

Keywords: Atopic dermatitis trace elements, alkaline phosphatase, severity scores