Meloxicam and diclofenac do not change VEGF and PDGF-AB serum levels of platelet-rich plasma

Authors: BURKAY UTKU, GÜRHAN DÖNMEZ, GÜLRİZ ERİŞGEN, ŞENAY AKIN, ALİ HAYDAR DEMİREL, FEZA KORKUSUZ, MAHMUT NEDİM DORAL

Abstract: Background/aim: Platelet-rich plasma (PRP) application has gained widespread interest for musculoskeletal injuries. Nonsteroidal antiinflammatory drugs are frequently used in sports medicine before and/or after PRP application. Our study seeks to determine whether serum levels of platelet-derived growth factor-AB (PDGF-AB) and vascular endothelial growth factor (VEGF) levels of PRP would be affected by nonsteroidal antiinflammatory drugs. Materials and methods: Two different final concentrations of diclofenac (0.5 6mu;g mL^-1 and 2.5 6mu;g mL^-1), meloxicam (0.8 μg mL^-1 and 2.0 μg mL^-1), and acetylsalicylic acid (final concentration 450 μm) were obtained in separate tubes with PRPs prepared from 20 healthy male volunteers. Medicine-free PRP was the control group. Growth factors were measured using ELISA. Results: PDGF-AB and VEGF serum levels did not change with diclofenac, meloxicam, or acetylsalicylic acid addition. PDGF-AB and VEGF serum levels correlated with each other. Conclusion: Diclofenac, meloxicam, and acetylsalicylic acid did not affect PDGF-AB and VEGF serum levels.

Keywords: Platelet-rich plasma, PDGF-AB, VEGF, nonsteroidal antiinflammatory drugs

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