Comparison of the effects of intradialytic parenteral nutrition alone and combined with anabolic steroid in patients undergoing hemodialysis therapy

Authors: ABDİ METİN SARIKAYA, FUNDA SARI, RAMAZAN ÇETİNKAYA

Abstract: It has been shown that androgen anabolic steroids and intradialytic parenteral nutrition (IDPN) may have advantages in malnourished hemodialysis patients. We aimed to compare the effects of IDPN and IDPN with added anabolic steroid. Materials and methods: Twenty hemodialysis patients who had albumin of <3.5 g/dL were included. Of those, 10 patients received 1000 mL of IDPN at each hemodialysis session 3 days per week, whereas the other 10 patients received IDPN plus nandrolone (100 mg intramuscularly) once every 2 weeks. Nutritional parameters were recorded at baseline and after 6 months. Results: In patients who received IDPN alone, significant elevations were found in albumin, total protein levels, and body weight (P < 0.05) after 6 months when compared with baseline values. In patients who received IDPN plus nandrolone, significant elevations were found in the same parameters (P < 0.05). Except for total cholesterol (P = 0.034), there were no differences in nutritional parameters between the 2 groups. Conclusion: Patients receiving IDPN for 6 months exhibited a significant increase in albumin levels. Adding nandrolone to IDPN treatment achieved no additional increase in these parameters; however, an increase in total cholesterol in the IDPN plus nandrolone group may be unfavorable at long-term follow-up.

Keywords: Hemodialysis, malnutrition, intradialytic parenteral nutrition, anabolic steroids

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