Effects of Growth Hormone on Bacterial Translocation Due to Intestinal Obstruction

Authors: AHMET A. BALIK, M. İLHAN YILDIRGAN, ALİ KILIÇ, CEMAL GÜNDOĞDU, FAZLI ERDOĞAN

Abstract: Bacterial translocation is an important etiologic factor in multisystem organ failure and sepsis, which have a high mortality rate. To determine the effects of growth hormone on bacterial translocation, an experimental study was performed. Twenty pathogen-free rabbits were divided into two groups each containing 10 rabbits. After loop obstruction was performed, the rabbits in the control group were given saline solution whereas the rabbits in the study group received growth hormone. Relaparotomy was performed after 24 hours, and tissue and blood samples were collected for histopathologic and microbiologic examinations. Bacterial translocation rates were higher in the control group than in the study group. In conclusion, the growth hormone was found to have protective effects against bacterial translocation.

Keywords: Bacterial translocation, growth hormone.

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