The Role of Leukotrienes in the Pathogenesis of Steroid-Sensitive Nephrotic Syndrome

Authors: Sevgi MİR, Afig HÜSEYİNOV, Mehmet KANTAR, Caner KABASAKAL, Alphan CURA, Işıl ÇOKER

Abstract: Endogenous leukotrienes (LT) levels in plasma and urine samples, and LT levels released from stimulated leukocytes in vitro were examined in children with steroid sensitive nephrotic syndrome (SSNS). Plasma LT concentrations were found to be higher in the SSNS group than in healthy subjects. Subjects with SSNS were also shown to have high levels of urinary cysteinyl-LTs and LTB 4 , while healthy children had only urinary LTE 4 levels. In the second part of the study, peripheral leukocytes of patients and heatlhy children were stimulated by Ca ionophore, A23187. We detected significantly higher levels of LTs in patients with SSNS suggest that leukotrienes, with their biological effects, might be involved in the pathogenesis of steroid sensitive nephrotic syndrome.

Keywords: Steroid sensitive nephrotic syndrome, inflammation, leukotrienes, calcium ionophore.

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