Therapeutic effects of intralipid and medialipid emulsionsin a rat model of verapamil toxicity

Authors: FATMA AKGÜN ŞAHİN, SIDIKA HÜLYA ÇELEBİ, İRFAN GÜNGÖR, DEMET COSKUN, ELİF ERGÜVEN KAYA

Abstract: Background/aim: Lipid emulsions are promising as a potential new therapy for severe verapamil overdose. Our purpose is to draw attention to the choice of solution by investigating the efficacy of intralipid 20% or medialipid 20% in verapamil overdose. Materials and methods: Eighteen adult Sprague Dawley rats were randomly divided into three groups: control (saline; Group C), intralipid 20% (Group I), and medialipid 20% (Group M). Rats were anesthetized with ketamine. Blood gas analysis, baseline heart rate (HR_b), and mean arterial pressure (MAP_b) were evaluated. Verapamil at 2.5 mg kg^-1 min^-1 was infused until the HR_b and MAP_b decreased by 50% and the times to HR₀ and MAP₀ were recorded. Treatment solutions of the groups were administered as 12.4 mL kg^-1 in 5 min. Results: While HR did not show a difference, MAP showed statistically significant differences among the groups. Intralipid 20% was more efficient than the other two treatments at an early stage; however, as the administration time progressed, medialipid 20% also turned out to be more efficient than the control treatment. Conclusion: Our findings indicate that in a toxicity model of rats produced with verapamil, intralipid 20% and medialipid 20% solutions partially eliminate cardiac-depressant effects and increase the survival rate.

Keywords: Verapamil, toxicity, cardiovascular collapse, intralipid, medialipid

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