Minor salivary gland evaluation: Sjögren?s syndrome

Authors: SÜLEN SARIOĞLU, ÜLKÜ KÜÇÜK, PINAR ÇETİN, İSMAİL SARI, AHMET MERİH BİRLİK

Abstract: Background/aim:1397645907We aimed to analyze the value of 3 serial sections, spaced 2001397645907μm1397645907apart,1397645907for quantification of lymphocyte and plasma cell foci in1397645907minor salivary gland biopsy (MSGB).1397645907 Materials and methods:1397645907Labial MSGBs from 69 patients with Sjögren's syndrome (SS) and scleroderma were used for this study. Each sample was prepared as 3 serial sections spaced 2001397645907μm apart.1397645907Lymphocytic and plasma cell focus score (LFS, PFS) were determined for each section, and the diagnostic results were compared to those obtained from a single section. Results: For 22 of the 69 patients, all 3 sections1397645907were scored at1397645907<1 and interpreted as inconclusive for the presence of SS. For 20 cases, all 3 sections1397645907were scored at1397645907?1 and interpreted as diagnostic for SS. In the remaining 27 cases, the score was found to vary between sections.1397645907Plasma cell foci were observed in 11 cases, with 5 cases exhibiting a PFS1397645907of ?1. Of those 5 cases, 4 also had a LFS1397645907of ?1. Conclusion:1397645907Assessment of 3 serial sections in MSGB has the potential to improve accuracy of SS diagnosis by detecting specific features that may not have been detected in a single section.1397645907We concluded that data about the PFS require further evaluation.

Keywords:  Sjögren?s syndrome, focus score, multilevel examination

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