Effects of Gingko Glycosid (EGb 761) on Some Vascular Endothelial Functions and Renal Histology in Rabbits With Acute Cyclosporine Nephrotoxicity

Authors: N. YILMAZ SELÇUK, BİRKAN YAKAN, MAHMUT BAŞOĞLU, CEMAL GÜNDOĞDU, AHMET KIZILTUNÇ, H. ZEKİ TONBUL, AYLA SAN

Abstract: In recent years, Endothelin-1 (ET-1), Platelet Activating Factor (PAF) and thromboxane have been considered responsible for the pathogenesis of acute cyclosporine nephrotoxicity (ACN). The aim of this study was to investigate the effects of the PAF antagonist gingko glycosid (EGb 761) on both renal histology and ET-1 and Nitric Oxide (NO) levels in experimental ACN. This study was carried out on 30 albino rabbits, divided into three groups. They were: group A (n=10) the control, group B (n=10), which was given intravenous cyclosporine (15mg/kg/day) and group C (n=10), which was given oral gingko glycosid (2.5mg/kg/day) in addition to cyclosporine. Plasma ET-1 and NO levels and renal histology were investigated in all of the groups. Data analysis was performed by Kruskall-Wallis one-way Anova and Mann Whitney-U tests. Plasma ET-1 levels in groups B and C were higher than in the controls (p<0.0002, p<0.0002, respectively). Plasma NO levels in groups B and C were lower than in the controls (p<0.0002, p<0.0047, respectively). However, group C had high NO levels and low ET-1 levels compared to group B (p<0.004, p<0.0002, respectively). Renal histological findings of ACN were observed in group B, and to a lesser extent in group C. Consequently, it was established that the PAF antagonist Gingko glycosid Egb 761 partially improved both the renal histology and plasma ET-1 and NO levels in experimental ACN.

Keywords: Acute nephrotoxicity, Cyclosporine, Gingko glycosid.

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