Age-related macular degeneration and Alzheimer disease

Authors: EREN ÇERMAN, MUHSİN ERASLAN, OSMAN ÇEKİÇ

Abstract: This review highlight the similarities in the pathogenesis between Alzheimer disease and age-related macular degeneration. All studies published between 1990 and 2014 were reviewed to identify the common pathological pathways. Alzheimer disease and age-related macular degeneration share common features such as vitronectin and amyloid-β accumulation, increased oxidative stress, and apolipoprotein and complement activation pathways, which are reviewed as histologic and immunologic common features.

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