Efficiency of Topical Treatment in Psoriasis with 1,25-Dihydroxycholecalciferol

Authors: Asuman BOZKIR, Erbak GÜRGEY, Hamide KAZERUNI

Abstract: The two different ointment concentrations of 1-25 (0H)2D3 were applied 45 person who were suffering psoriasis. These were the best formulas which have been used untill this time. when 100µg/g 1-25 (0H)2D3 ointments which had been applied for about 8 weeks, in 78.2% causes have been completely recovered, the other 17.4% have been mild, the other 4.4% have been limited recovery. When we applied 50 µg/g of 1-25 (0H)2D3 ointment for about 9 weeks in the case of 63.7% have been full recovery, the case of 22.8% have been moderate, 4.5% have been limited recovery was seen. In the case of 9%, the ointment have not been effected. In this study, different types of psoriasis vulgaris were taken. These two concentration and the recovery time analysed by statistical test. We observed that, in all types of psoriasis vulgaris, the time of recovery and the concentration of 1-25 (0H)_2D_3 ointment showed direct proportion (p<0.05). During the therapy we have not seen topic and systemic side effecct.

Keywords: Psoriasis vulgaris, 1,25-Dihydroxycholecalciferol.