Prevalence of Diabetic Nephropathy in Turkish Children with Insulin-Dependent Diabetes Mellitus

Authors: AYŞENUR ÖKTEN, GÜLAY KAYA, GÜLAY KARAGÜZEL, YUSUF GEDİK, MUHTEREM ÖZDEMİR

Abstract: This study was involved with determining the prevalence of diabetic nephropathy in 72 Turkish children with insulin-Dependent diabetes mellitus. Diabetic nephropathy was diagnosed with blood pressure levels, glomerular filtration rate, albumin excretion rate, ?-2 microglobulinuria and kidney length. There wereo significant differences between laboratory data for boys and girls, but adolescent patients had significantly higher albumin excretion rates than preadolescent patients (p<0.05). The mean kidney length of the diabetic patients was 1-2 cm longer than in health children. It was found that the prevalence of clinical diabetic nephropathy in pediatric patients with insulin-dependent diabetes mellitus was 5.5%. Four patients who were diagnosed as having diabetic nephropathy were given ACE inhibitors and were put under strict metabolic control. The progression of the disease reversed in two patients. However, in the other two end stage renal failure developed. This may be due to some unexplained genetic factor as well as the patients' ages. In order to prevent diabetic nephropathy the conventional two dose insulin regimen was abandoned and a new intensive insulin regimen was adopted.

Keywords: Insulin-dependent diabetes mellitus, diabetic nephropathy, prevalence.

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