Pregnancy and its outcomes in hemodialysis patients in Turkey

Authors: HAMAD DHEİR, ÖZKAN GÜNGÖR, MEMNUNE SENA ULU, EBRU GÖK OĞUZ, NECMİ EREN, ORÇUN ALTUNÖREN, ERHAN TATAR, KADİR GÖKHAN ATILGAN, SÜLEYMAN KARAKÖSE, İBRAHİM GÜNEY, ERAY EROĞLU, RÜYA MUTLUAY, İLTER BOZACI, ALPER ALP, HAKAN AKDAM, MELTEM SEZİŞ DEMİRCİ, ZEKİ SOYPAÇACI, ÖZGER AKARSU, SAİME PAYDAŞ, ZAFER ERCAN, EKREM KARA, CEVAT TOPAL, HALDUN HAKAN YAVAŞ, NİHAN TEKKARIŞMAZ, KENAN TURGUTALP, CAN HÜZMELİ, AYÇA İNCİ, GÜNER KARAVELİ GÜRSOY, AYŞE JİNİ GÜNEŞ KESKİN, BÜLENT HUDDAM, ENDER HÜR, ABDULMECİT YILDIZ, GARİP BEKFİLAVİOĞLU, TUNCAY ŞAHUTOĞLU, MEHMET TUNCAY, SİMGE BARDAK, SERKAN BAKIRDÖĞEN, ZÜLFÜKAR YILMAZ, EMRAH GÜNAY, ONUR TUNCA, SİNAN KAZAN, İREM PEMBEGÜL YİĞİT, HAZEN SARITAŞ, CAN SEVİNÇ, HAKAN KAPTANOĞULLARI, SİBEL GÖKÇAY BEK, İLHAN KURULTAK, ALİ DEĞİRMENCİ, MURAT ŞAKACI, İLHAN KILIÇ, ZEKİ AYDIN, HÜLYA ÇOLAK, ERKAN DERVİŞOĞLU, GARİP ŞAHİN, MEHMET DENİZ AYLI, SAVAŞ SİPAHİ, ÜLVER DERİCİ

Abstract: Background/aim: This study aimed to investigate pregnancy frequency and evaluate the factors affecting live births in hemodialysis (HD) patients. Materials and methods: Female HD patients whose pregnancy was retrospectively reported between January 1, 2014, and December 31, 2019. The duration of HD, primary disease, and the information on whether the pregnancy resulted in abortion, stillbirth, or live birth, whether the HD duration was prolonged after diagnosing the pregnancy and whether it accompanied preeclampsia were recorded. Results: In this study, we reached 9038 HD female patients' data in the study. A total of 235 pregnancies were detected in 145 patients. The mean age was 35.42 (35 ± 7.4) years. The mean age at first gestation was 30.8 ± 6.5 years. The average birth week was 32 (28-36) weeks. A total of 53.8% (no = 78) of the patients had live birth, 51.7% (no = 70) had at least one abortion in the first 20 weeks, and 13.1% (no = 19) had at least one stillbirth after 20 weeks. The rate of patients' increased numbers of dialysis sessions during pregnancy was 71.7%. The abortion rate was 22.4% in those with increased HD sessions, whereas 79.3% in those not increased HD sessions (p < 0.001). Live birth frequency was 67.2% in the increased HD sessions group and 3.4% in those who did not differ in HD sessions (p < 0.001). Conclusion: For the first time, we reported pregnancy outcomes in HD female patients, covering all regions of Turkey. It has been observed that; increasing the number of HD sessions in dialysis patients will decrease fetal and maternal complications and increase live birth rates.

Keywords: Chronic renal failure, hemodialysis, pregnancy, dialysis session, fatal outcome, infertility

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