Experimental Pancreatic Adenocarcinoma in Rats After Subcutaneously Injection of Azaserine: A Light Microscopy Study of Development of Acinar Cell Adenoma

Authors: Haydar ÖZTAŞ, H. Zeki TONBUL, N. Yılmaz SELÇUK, Birkan YAKIN

Abstract: In the present study, we have described the morphologic features of development of acinar cell carcinoma in high resolution light microscopy. Recent preliminary results from autopsy cases indicated that human pancreatic cancer shares some simiarity with equivalent tumours in the expremental model, on of the major findings being that prenoplastic and neoplastic lesions of acinar cell origin appear in both species. In high resolution light microscopy, the tumour cells featured with an abundant of acculation of secreted granules in acinar lumens and poorly differentiated acinar structure. In additon there was a progressive increase in abnormal acini, frequently with loss of polarity and bizarre nuclei, whose cells show marked variations in size, vacuolation of the cytoplasm and decreased density of staining. Intrafibrotic spreading of the tumour was a common manifestation of potentially malignant acinar cell tumour.

Keywords: acini, azaserine, pancreas, carcinoma