Plasma Fibronectin and Urine Glycosaminoglycane Levels in Rheumatic Diseases

Authors: Nuriye METE, Mahmut METE, İ. Hakkı ÖZTÜRK, Leyla ÇOLPAN

Abstract: In this study, plasma fibronectin and urine glycosaminoglycane levels were determined spectrophotometrically in 20 Rheumatoid arthritis, 10 Ankilosing spondilites, 22 osteoarthrosis and 21 healthy control subjects. The mean levels of Fibronectin (\mug/ml) were 413.3±97 in patients with rheumatoid arthritis, 325.5±93.5 in ankilosing spondilites, 439.1±120.3 in osteoarthrosis and 302.2±60.1 in the control group. The ratio of urine glycosaminoglycan excretion to creatinine (g/mol) was 4.52±2.64 in patients with rheumatoid arthritis, 4.18±1.52 in patients with ankilosing spondilites, 2.72±1.19 in osteoarthrosis and 2.21±1.02 in the control group. Plasma Fibronectin levels were significantly higher in rheumatoid arthritis and osteoarthrosis when compared to the control group (p<0.001). The ratio of urinary glycosaminoglycans excretion to creatinine levels in patients with rheumatoid arthritis and ankilosing spondilites were significantly greater when compared with control group (p<0.001). Having established that plasma fibronectin levels and urine glycosaminoglycane/creatinine ratio were important laboratory findings in rheumatic diseases, and it was decided to employ further research to englihten mechanisms that are still controversial.

Keywords: Rheumatic disease, fibronectin, glycosaminoglycane.

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