The Effect of Treatment Types on Plasma Levels of Lipoproteins, Apolipoproteins and LCAT in Type II Diabetes Mellitus

Authors: Eser VARDARELİ, Belgin EFE, Fahrettin AKYÜZ, Mine İNAL, Esat ERENOĞLU

Abstract: In this studry 32 hyperglycemic patients with type II DM were treated with diet (7 patients), with gliclazide, an oral antidiabetic agent (10 patients), or with insulin (15 patients). The levels of liporoteins, apolipoprotein A and B and LCAT enzyme are measured before the therapy and 3 weeks after the achievement of glycemic control. Treatment types are compared with each other and with control group (10 normal persons) triglyseride (TG) and VLDL levels which were found to be high in all of the patients decreased in all groups to levels similar to control group. TC (total cholesterol), LDL, TC/HDL, LDL/HDL levels found high before treatment in the OAD (oral antidiabetic) group (p<0.05) were similar to control values after treatment in the OAD levels of all groups before the treatment were similar to control group, but afterwards it was significantly high in the OAD group. Apo B level decreased after the therapy only in the OAD group (p<0.05). The higher levels of Apo B/Apo A in the OAD and insulin group before the treatment declined in both groups with the therapy and were indifferent from control group in the OAD group. LCAT levels didn't change in any of the conditions. Between treatment groups there was no difference in lipoprotein, Apo A, Apo B and LCAT levels before and after the treatment. There was a positive correlation between fasting blood glucose level (FBGL) and TG and Apo B/Apo A, insulin level and Apo B and Apo B/Apo A, TG and T.C, Apo B and LDL/HDL, LDL and Apo B, HDL and Apo A, but a negative correlation between the activity and insulin level and macrovascular complications of the disease, HDL and proteinuria. In conclusion, in patients with uncontrolled type II DM lipid metabolism in altered and with achievement of metabolic control these alterations regress independent of treatment type and the most beneficial alteration has been observed in the OAD group.

Keywords: Diabetes Mellitus, Plasma Lipoproteins, Apolipoproteins, LCAT.

Full Text: PDF