An Immunohistochemical Study of Gastric Neuroendocrine Tumors: Expression of Proliferating Cell Nuclear Antigen and P53 Oncoprotein

Authors: GÜLEN DOĞUSOY, SÜHA GÖKSEL, IŞIL PAKİŞ, HAYDAR DURAK, GÖKHAN ERSOY, SELDA GÖÇENER

Abstract: The aim of this study is to examine expression of Proliferating cell nuclear antigen (PCNA) and p53 oncoprotein in gastric neuroendocrine tumors. 35 gastric neuroendocrine tumors were analyzed for first histopathologic features and then, immunohistochemical study was done to detect labeling index of PCNA and accumulation of p53 protein by using monoclonal antibodies and the Labeled strepavidin-biotin method. PCNA labeling index and p53 protein expression were compared with histopatholoic features in statistical methods of Fisher's exact, chi square and logistic regression tests. No significant correlation was found between them except PCNA score and depth of invasion. In conclusion, our findings show that not p53 but PCNA appears to be useful in detecting malignant potential of these tumors.

Keywords: Gastric neuroendocrine tumors, PCNA, p53 oncoprotein.

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