S-Aroylmethyl N, N-Disubstituted Dithiocarbamates With Antiparkinson Activity

Authors: RAHİME ŞİMŞEK, CİHAT ŞAFAK, KEVSER EROL, KAMİL VURAL

Abstract: Seven S-aroylmethyl N,N-disubstituted dithiocarbamate derivatives have been synthesized and their effects on oxotremorine induced tremor have been investigated on mice pretreated with the proparkinsonian drug haloperidol. While the compound 1f inhibited oxotremorine-induced tremors at doses of 50 mg/kg and 100 mg/kg levels, compounds 1a, 1c and 1e had this effect at the dose of 100 mg/kg. The compounds 1b, 1d and 1g had no effect on oxotremorine-induced tremors in mice. These results suggest that some of these derivatives have central antimuscarinic effects and antiparkinson activities.

Keywords: Dithiocarbamate, antiparkinson activity

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