Pyrazinamide monoresistance in clinical isolates

Authors: NEZAKET KALIR, AYŞE AYDAN ÖZKÜTÜK, NURAN ESEN, NURİ ÖZKÜTÜK

Abstract: To determine pyrazinamide (PZA) monoresistance in clinical isolates of Mycobacterium tuberculosis complex (MTBC) isolated in hospitals in and around İzmir. Materials and methods: The study was performed between 2004 and 2009 with 150 streptomycin, isoniazid, rifampicin, and ethambutol susceptible MTBC clinical strains isolated in the university hospitals of İzmir and Manisa. The PZA susceptibility of the isolates was determined by the BACTEC 460 TB test. Results: The results indicated that resistance to PZA was present in 5 (3.3%) of the 150 MTBC isolates susceptible to all primary drugs except PZA. Conclusion: It is not essential to perform PZA susceptibility tests routinely along with other primary drugs due to the low PZA monoresistance level in our region.

Keywords: Mycobacterium tuberculosis, antituberculosis susceptibility test, pyrazinamide resistance, BACTEC 460TB

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