Pleuroparenchymal fibroelastosis in systemic sclerosis-associated interstitial lung disease

Authors: ALPER SARI, ÖMER ÖNDER, BERKAN ARMAĞAN, ERTUĞRUL ÇAĞRI BÖLEK, BAYRAM FARİSOĞULLARI, EMRE BİLGİN, GÖZDE KÜBRA YARDIMCI, ORHAN MACİT ARIYÜREK, ALİ AKDOĞAN

Abstract: Background/aim: To explore the frequency and clinical associations of radiologic pleuroparenchymal fibroelastosis (PPFE) in patients with systemic sclerosis-associated interstitial lung disease (SSc-ILD). Materials and methods: In this single-center retrospective study, high resolution computed tomography (HRCT) images of 105 patients with SSc-ILD were examined for the presence of PPFE. Demographic, clinical, laboratory, and pulmonary function test (PFT) data of patients with and without PPFE were compared. Results: PPFE was detected in 19 (18.1%) patients (`definite PPFE' in 13 and `consistent with PPFE' in 6 patients). Patients with PPFE had higher age and longer disease duration than PPFE (-) patients (p < 0.05 for both). Radiologic usual interstitial pneumoniae (UIP) pattern was more frequent (26.3% vs. 4.7%, p = 0.01) and median force vital capacity (FVC) was lower in patients with PPFE (64% vs. 82%, p = 0.005). Spontaneous pneumothorax developed in one patient with PPFE. More deaths occured in PPFE (+) group during follow-up (31% vs. 11%, p = 0.04). Conclusion: PPFE on HRCT is not uncommon in SSc-ILD and is associated with radiologic UIP pattern and worse lung functions. Further studies are needed to elucidate the prognostic value of PPFE in SSc-ILD.

Keywords: Systemic sclerosis, interstitial lung disease, pleuroparenchymal fibroelastosis

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