Common variable immunodeficiency in adults requires reserved protocols for long-term follow-up

Authors: AHMET ZAFER ÇALIŞKANER, İSMAİL REİSLİ, ŞEVKET ARSLAN, RAMAZAN UÇAR, HÜSEYİN ATASEVEN, NEDİM YILMAZ SELÇUK

Abstract: Background/aim: The aim of this study is to establish follow-up protocols for adult patients with common variable immunodeficiency (CVID) in a recently founded adult immunology clinic in the Central Anatolia Region of Turkey, where a clinical immunology center for adults was not available previously. Materials and methods: A total of 25 patients with CVID aged 18 years and older were included in this study. The file format consisted of 13 pages and was developed for the purpose of the study. Separate sections were designated for identity information, medical history, disease course, previous and current laboratory and imaging studies, follow-up plans, detection and management of complications/comorbidities, and treatment results. Results: The mean age of the patients was 36.6 ± 13.4 years. The delay in diagnosis was 107 ± 95.6 months. In 92% of patients, initial symptoms resulting in admission to healthcare facilities were infections. Seventeen of 25 patients (68%) had bronchiectasis at the beginning of follow-up. Conclusion: Early identification of complications and comorbidities in patients with CVID will significantly improve quality of life and survival. Close observation and standardized protocols for follow-up are essential components of management.

Keywords: Common variable immunodeficiency, CVID in adults, CVID management, CVID follow-up

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