Does the course of laboratory parameters help us to predict the outcome of CCHF?

Authors: SÜMEYYE KAZANCIOĞLU, ESRAGÜL AKINCI, ALİYE BAŞTUĞ, BİRCAN KAYAASLAN, AYŞE BUT, HALİDE ASLANER, SELİM SIRRI EREN, MELTEM ARZU YETKİN, HURREM BODUR

Abstract: Abstrat Background/aim: This study was performed to identify the characteristics distinguishing fatal and nonfatal cases of patients diagnosed with Crimean-Congo hemorrhagic fever (CCHF). Materials and methods: A total of 92 patients with confirmed diagnosis of CCHF in 2009-2013 were included in the study. Results: A high level of urea and aPTT on the third day of hospital stay, diarrhea, somnolence, and the interval from the beginning of the symptoms to hospital admission were independently associated with fatality. Each 10-unit increase in aPTT and urea levels increased the fatality rate by 3.379-fold and 1.236-fold, respectively. Delay in hospital admission increased the fatality rate 1.453-fold for each day of delay. When comparing first and third admission-day laboratory values, the increase in leukocyte counts and the decrease in CPK, urea, creatinine, aPTT, PT, INR, and hemoglobin levels were significant in nonfatal cases. Conclusion: This study showed that the course of these laboratory tests helps us to predict the outcome of the disease. In a few days of hospitalization, persistence or progress of the abnormal laboratory parameters may warn us about poor prognosis.

Keywords: Crimean?Congo hemorrhagic fever, mortality, severity criteria

Full Text: PDF