Microwave hyperthermia application with bioimplant single slot coaxial antenna design for mouse breast cancer treatment

Authors: AHMET RİFAT GÖRGÜN, CEM BAYTÖRE, SELÇUK ÇÖMLEKÇİ, MEHMET İBRAHİM TUĞLU, ADNAN KAYA

Abstract: In this study, a novel animal model for the breast cancer treatment which contains hyperthermia is proposed. For this main purpose a low cost, interstitial, bioimplant antenna by short ended single slot design is proposed to heat the cancerous tissues. Both the theoretical background of the proposed system and the simulation and measurement results of antenna design are presented. An artificial tissue phantom model has been created under laboratory conditions and then the utility of the proposed antenna has been tested on this model. Artificial tissues have been heated by 25W to (41-44 ? C) in a short time like 25 s. Temperature measurement is performed in real-time and wireless by a digital temperature sensor using an embedded system platform. In addition, the effectuality of the proposed hyperthermia system has been tested by the study on live mice. For this purpose, breast cancer tissues created under laboratory conditions have been transferred to experimental group Balb/c mice to induce breast cancer. According to the results of hyperthermia treatment, the breast cancer has been inhibited by the proposed hyperthermia system. All studies have been animal care with ethics committee approval. All experiments have been repeated three times by at least two observers independently. The results of this study give hope that the breast cancer treatment method using this new antenna could be used in humans in the future. For this, the number of such types of ablation studies using this type of antenna should increase.

Keywords: Microwave heating, hyperthermia, breast cancer treatment, coaxial antenna, in vivo, Balb/c mice

Full Text: PDF