Synthesis and Biological Activity of Allosteric Modulators of GABA_B Receptors. Part 4. Synthesis of Potentially Fluorescent Acridines and Conformationally Restricted N-(arylpropyl)-1-arylethylamines

Authors: JABBAR KHALAFY, ROLF H. PRAGER, NI MADE PUSPAWATI

Abstract: A series of 8 new derivatives of fendiline was prepared for evaluation as allosteric modulators of GABA_B receptors: 4 based on acridine and 4 with restricted distance between the 2 aryl moieties.

Keywords: Fendiline analogues, acridines, acridones, aminotetralins, aminoindanes, GABA.

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