Synthesis, X-ray Structure, and Bioassay of Newly Synthesized Trimethyltin(IV) 2,3-Methylenedioxy Benzoate

Authors: MUKHTIAR HUSSAIN, MUHAMMAD HANIF, SAQIB ALI, SAIRA SHAHZADI, HELEN S. EVANS

Abstract: Trimethyltin(IV) complex containing the carboxylate ligand 2,3-methylenedioxybenzoic acid (HL) have been synthesized and characterized in solution state by multinuclear NMR (^1H, ^{13}C and ^{119}Sn) using the noncoordinating solvent and also in solid sate by FTIR, mass spectrometry, and X-ray crystallography. Spectroscopic data have shown that methylenedioxy moiety has not coordinated with tin atom; instead, the coordination site is a -COO group, which is proved by spectral and XRD data. The solid state structure shows the trigonal bipyramidal geometry with a space group P2_1/c. This compound was tested for its in vitro antitumor activity.

Keywords: 2,3-methylenedioxybenzoic acid, spectroscopy, X-ray structure, antitumor activity

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