Synthesis and Antimicrobial Activity of Some New 3-Substituted Benzyl-5-(4-chloro-2-piperidin-1yl-thiazole-5-yl-methylene)-thiazolidine-2,4-dione Derivatives

Authors: MELTEM CEYLAN ÜNLÜSOY, OYA BOZDAĞ DÜNDAR, NURTEN ALTANLAR, RAHMİYE ERTAN

Abstract: A new series of thiazolyl thiazolidine-2,4-dione (Va-f) were synthesized and their structures were elucidated by IR, ^1H-NMR, mass spectra and elementary analysis. The synthesized compounds were tested for their antimicrobial activities against Candida albicans, Staphylococcus aureus, Bacillus subtilis and Escherichia coli. Compounds Va-b, Vd-f showed high activity against Escherichia coli comparable to ampicillin.

Keywords: Thiazolidine-2,4-diones, thiazole derivatives, antimicrobial activities

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