Synthesis of New 4-(5-Chloro-2-oxo-3H-benzoxazol-3-yl)butanamide Derivatives and Their Analgesic and Anti-Inflammatory Properties

Authors: H. OZAN GÜLCAN, SERDAR ÜNLÜ, ERDEN BANOĞLU, M. FETHİ ŞAHİN, ESRA KÜPELİ, ERDEM YEŞİLADA

Abstract: In this preliminary screening study for developing potent analgesic and anti-inflammatory compounds, eight new 4-(5-chloro-2-oxo-3H-benzoxazol-3-yl)butanamide derivatives were synthesized and screened for their analgesic and anti-inflammatory activities as well as gastric ulceration potential in tested animals. Their structures were elucidated by their IR, ^{1}H-NMR and elemental analysis. All of the compounds exhibited high analgesic and anti-inflammatory activities. None of the compounds except compound 2g caused gastric lesions or bleeding in tested animals.

Keywords: 2-Oxo-3H-benzoxazole, butanamide, analgesic, anti-inflammatory, COX-1, COX-2.

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