Synthetic access to some new benzothiazole-based 1,3,4-thiadiazole and 1,3-thiazole derivatives

Authors: KAMAL M. DAWOOD, EMAN A. RAGAB, KORANY A. ALI

Abstract: 1-(Benzothiazol-2-yl)-3-phenylthiourea\textbf{ 2} was prepared and treated with hydrazonoyl chlorides \textbf{3a}--\textbf{e }to yield the corresponding 5-(benzothiazol-2-ylimino)-1,3,4-thiadiazole derivatives \textbf{6a}--\textbf{e}, respectively. Reaction of the thiourea derivative \textbf{2} with ethyl 2-chloro-3-oxobutanoate \textbf{9} afforded the corresponding 2-(benzothiazol-2-ylimino)thiazole-5-carboxylate derivative \textbf{11}. The newly synthesized heterocyclic derivatives were confirmed from their elemental and spectral analyses.

Keywords: Benzothiazole, thiazole, thiadiazole, thiourea, hydrazonoyl chlorides

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