Microwave-assisted synthesis of novel 8-chloro-[1,2,4]triazolo[4,3-$a$]pyridine derivatives

Authors: LINJIONG ZHANG, MINGYAN YANG, BEIZHEN HU, ZHAOHUI SUN, XINGHAI LIU, JIANQUAN WENG, CHENGXIA TAN

Abstract: A series of novel 1,2,4-triazolo[4,3-$a$]pyridine derivatives were synthesized from 2,3-dichloropyridine and hydrazine hydrate as starting materials by multistep reactions under microwave assistance, and their structures were characterized by $^{1}$H NMR, MS, and elemental analysis. This method provides several advantages such as high yields, facile work-up, and environmental friendliness.

Keywords: 1, 2, 4-Triazolo[4, 3-$a$]pyridine, urea, microwave-assisted synthesis

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