Calixpenams: synthesis, characterization, and biological evaluation of penicillins V and X clustered by calixarene scaffold

Authors: FAZEL NASUHI PUR, KARIM AKBARI DILMAGHANI

Abstract: Four 6-aminopenicillanic acid moieties were grafted at either rim of calix[4]arene, giving 2 novel generations of penicillin, which were named calixpenam. Antibiotic tests showed that they have amplified activity with respect to the corresponding penams against 3 gram-positive nonpenicillinase-producing strains of Streptococcus.

Keywords: Calixpenam, Calixarene, 6-aminopenicillanic acid, nonpenicillinase, Streptococcus strains

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