N-functionalized benzimidazol-2-ylidene silver complexes: synthesis, characterization, and antimicrobial studies

Authors: YETKİN GÖK, SENEM AKKOÇ, ÖZLEM ÖZEROĞLU ÇELİKAL, İLKNUR ÖZDEMİR, SELAMİ GÜNAL, ELİF SAYIN

Abstract: 2-Methoxyethyl, 2-diethylaminoethyl, and 2-phenylethyl-substituted N-heterocyclic carbene (NHC) precursors were treated with Ag_2CO_3 to yield silver(I)-NHC complexes (1a--g) in dichloromethane as a solvent at room temperature. The 7 new silver-NHC complexes were fully characterized by means of ^1H NMR, ^{13}C NMR, and elemental analysis techniques. Using the agar dilution procedure recommended by the Laboratory and Clinical Standards Institute, the antimicrobial activities of all the silver-NHC complexes were studied against 2 gram-negative bacterial strains (Pseudomonas aeruginosa and Escherichia coli), 2 gram-positive bacterial strains (Enterococcus faecalis and Staphylococcus aureus), and 2 fungi (Candida tropicalis and Candida albicans).

Keywords: N-Heterocyclic carbene, benzimidazol-2-ylidene, silver complex, antimicrobial activity, medical inorganic chemistry

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