Silica nanoparticles as a high efficient catalyst for the one-pot synthesis of 3-oxo-3-phenylpropanamid derivatives from isocyanides, phenylacetaldehyde and secondary amines

Authors: ALI RAMAZANI, KOUROSH DASTANRA, FATEMEH ZEINALI NASRABADI, ZAHRA KARIMI, MORTEZA ROUHANI, MEHDI HOSSEINI

Abstract: Reaction of an isocyanide with an iminium ion intermediate, formed by reaction between 2-oxo-2-phenylacetaldehyde and a secondary amine in the presence of silica nanoparticles, proceeds smoothly at room temperature to afford ketoamide derivatives in high yields.

Keywords: Silica nanoparticles, multicomponent reaction, isocyanide, 2-oxo-2-phenylacetaldehyde, secondary amine, iminium ion

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