Synthesis, characterization, and antioxidant activities of new trisubstituted triazoles

Authors: KEMAL SANCAK, YASEMİN ÜNVER, DİLEK ÜNLÜER, ESRA DÜĞDÜ, GÜLCAN KÖR, FATİH ÇELİK, EMRAH BİRİNCİ

Abstract: A series of new 4-(3,4dimethoxyphenethyl)-3,5-akyl/aryl-4H- 1,2,4-triazoles (3a-g) were obtained by reaction of ethyl N'-(alkylidene/arylidene)hydrazonate (1) and 2-(3,4-dimethoxy phenyl)ethanamine (2). Compounds 4d, e, and g were synthesized from the reaction of corresponding compounds 3d, e, and g with BBr_3, respectively. The 10 new compounds synthesized were characterized by elemental analyses, IR, ^1H-NMR, and ^{13}C-NMR spectral data. The structure of compound 3g was inferred through IR, ^1H-, ^{13}C-NMR, elemental analyses, and X-ray spectral techniques. In addition, the newly synthesized chemicals were screened for their antioxidant properties. Among the chemicals tested, 4d, e, and g exhibited the highest degree of antioxidant activity.

Keywords: Synthesis, 1,2,4-triazole, antioxidant activity, boron tribromide, X-ray

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