Tridentate ligands derived from L-tert-Leucine for the Cu(II) mediated asymmetric Henry reaction

Authors: NESLİHAN KORKMAZ, DEMET ASTLEY, STEPHEN THOMAS ASTLEY

Abstract: Chiral tridentate Schiff base ligands were prepared from L-tert-Leucine and used as catalysts in the asymmetric Henry reaction in the presence of Cu(II) ions. Moderate enantiomeric excesses (up to 66%) and yields (up to 76%) of the desired \beta-nitroalcohols were obtained.

Keywords: Asymmetric Henry reaction, chiral Schiff base, L-tert-Leucine, amino alcohol, tridentate ligand

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