Silk fiber-based composite nanofiber tissue scaffold produced with electrospinning method

Authors: METİN YÜKSEK, MEHMET AKALIN, ERHAN SANCAK, ERKAN İŞGÖREN, ONUR ATAK, DERYA SALTIK ÇİRKİN, ALİ BEYİT

Abstract: Wound dressings are one of the most rapidly expanding areas in medical textiles. In recent years, a large number of functional wound dressing has been developed. The aims of these products are to speed up the wound healing process and to provide maximum comfort for patients. Today, the multidisciplinary studies are required to improve further existed wound dressings. The results of such research studies are also promised new hopes for the Turkish textile industry weakened by the global competition. For this purpose, three different polymers were selected as silk fibroin (SF) / polycaprolactone (PCL) / polyethylene oxide (PEO). The productions were made using triple and doublex mixture polymers and single polymer. It has been observed that the SF/PCL/PEO solution has extremely good viscosity, and conductivity values, fiber diameter, and structure thickness have the highest values. SF/PCL/PEO structure has a middle level in the strength value. It has been observed that the PCL polymer plays an effective role in the strength value. The most effective result for S group mats was seen in S2 (PCL/PEO) mat with a 2.62% reduction against the HaCaT cell line. A nanofiber tissue scaffold was produced by the electrospinning method, and a structured candidate for use was obtained by improving performance.

Keywords: Silk fibroin, polycaprolactone, polyethylene oxide, electrospinning

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