Novel vic-dioximes: synthesis, structure characterization, and antimicrobial activity evaluation

Authors: DUMITRU URECHE, ION BULHAC, ALEXANDRU CIOCARLAN, DANIEL ROSHCA, LUCIAN LUPASCU, PAULINA BOUROSH

Abstract: The vic-dioximes are compounds with various industrial uses and scientific applications. Many coordination compounds have been synthesized based on vic-dioximes. This study presents the synthesis and full characterization of two vic-dioximes based on dichloroglyoxime, p-aminobenzoic acid, and p-aminotoluene. Their structures were proved by IR, ¹H, ¹³C and ¹⁵N NMR spectral analysis, and single crystal X-ray diffraction. One of the reported vic-dioximes, bis(di-p-aminotoluene)glyoxime mono-p-aminotoluene trihydrate showed good to moderate antimicrobial activity against both nonpathogenic gram-positive and gram-negative bacteria (Bacillus subtilis and Pseudomonas fluorescens), phytopathogenic (Xanthomonas campestris, Erwinia amylovora, E. carotovora) and the fungi (Candida utilis and Saccharomyces cerevisiae) at MIC - 70-150 μg/mL.

Keywords: vic-dioxime, spectral analysis, X-ray diffraction, antibacterial activity, antifungal activity

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