Determination of characterization, antibacterial and drug release properties of POSS-based film synthesized with sol-gel technique

Authors: İDİL KARACA AÇARI, SÜLEYMAN KÖYTEPE, BURHAN ATEŞ, İSMET YILMAZ, TURGAY SEÇKİN

Abstract: In the study, antibacterial film synthesis was aimed using sol-gel technique from POSS structure with various functional groups. For this purpose, antibacterial properties have been acquired by metronidazole to the films to be synthesized. The films obtained were coated on glass surface samples by dip coating method. Antibacterial activities of surface coated glass samples were observed in E.coli and S. aureus bacteria. Metronidazole release studies in the film samples were followed by UV spectrophotometer. It was observed that drug release reached 68.90% at the end of the 24th h. As a result, it is thought that the synthesized film will be a good candidate especially for biomedical surface coating areas.

Keywords: Polyhedral oligomeric silsesquioxane, dip coating, antibacterial activity, drug delivery

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