Transition Metal Compound Mediated Reduction of \alpha-Amino Acids to 1,2-Amino Alcohols with NaBH_4 in Water

Authors: AYHAN S. DEMİR, İDRIS M. AKHMEDOV, ÖZGE ŞEŞENOĞLU

Abstract: A new efficient and cost-effective method for the preparation of 1,2-amino alcohols is described. The reactions of amino acids with NaBH_4 in the presence of NiCl_2 or MoO_3 in water give 1,2-amino alcohols in high yield. When optically pure amino acids were used, optically pure 1,2-amino alcohols were obtained.

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