A Mild Method for the Cleavage of Ketals Using IBX

Authors: ABDUL RAUF RAZA

Abstract: Investigation on the total synthesis of batrachotoxin 1 revealed that the cyclic ketals could be cleaved to ketone with IBX in DMSO at 70-81 °C under very mild conditions. A variety of functional groups showed no interference under these conditions except vinyl bromides, which, in fact, inhibits the single electron transfer to IBX.

Keywords: Deprotection, ketal, IBX, ketone, single electron transfer, batrachotoxin.

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