Nepetalactones and Other Constituents of Nepeta nuda ssp. Albiflora

Authors: GAMZE KÖKDİL, SABİHA M. YALÇIN, GÜLAÇTI TOPÇU

Abstract: The hexane extract of Nepeta nuda ssp. albiflora led to the isolation of six known monoterpene nepetalactones, 4a\alpha,7\alpha,7a\alpha-nepetalactone (1), 4a\alpha,7\alpha,7a\beta-nepetalactone (2), 4a\beta,7\alpha,7a\beta-nepetalactone (3), 4a\beta,7\alpha,7a\alpha-nepetalactone (4), 4a\alpha,7\beta,7a\beta-nepetalactone (5), 3\alpha-hydroxy-4a\alpha,7\alpha,7a\alpha-dihydron\-epe\-tal\-actone (=nepetalic acid) (6) and a dimeric 5,9-dehydronepetalactone (7) along with two known steroids \beta-sitosterol and sitosterol 3-one and a triterpene betulinic acid. The acetone extract of the same plant afforded compound 7 in a higher yield in addition to compounds 2 and 6, and sesquiterpene caryophyllene oxide, the iridoid glucoside 1,5,9-epideoxyloganic acid, the triterpenoids oleanolic, ursolic and betulinic acids, and sitosterol 3\beta-glucoside.

Keywords: Nepeta nuda ssp. albiflora; Lamiaceae; nepetalactones; dimeric 5,9-dehydronepetalactone ; sesquiterpene; triterpenoids; steroids.

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