An efficient one-pot synthesis of dihydropyrimidinones catalyzed by zirconium hydrogen phosphate under solvent-free conditions

Authors: MUSTAFA KÜÇÜKİSLAMOĞLU, ŞENOL BEŞOLUK, MUSTAFA ZENGİN, MUSTAFA ARSLAN, MEHMET NEBİOĞLU

Abstract: A simple, efficient, and practical procedure for the Biginelli reaction using zirconium hydrogen phosphate [Zr(H_2PO_4)_2] as a novel solid acid catalyst is described under solvent-free conditions in high yields. The catalyst exhibited remarkable reactivity and it is reusable.

Keywords: Biginelli reaction; solvent-free; zirconium hydrogen phosphate; dihydropyrimidinones, recyclable catalyst

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