Polarographic Determination of Fluvoxamine Maleate in Tablets

Authors: FİKRİYE ELMALI, GÜZİN ALPDOĞAN, SIDIKA SUNGUR, ŞULE AYCAN

Abstract: The differential pulse polarographic (DPP) method was developed for the determination of fluvoxamine maleate (I). At pH = 3. 7, (I) give a peak at - 0. 73 V in aqueous solution. The developed method was applied to the assay of the drug substance in commercial tablet formulations. The results were statistically compared with those obtained by reference methods (HPLC and direct current polarographic method) using t- and F- tests at 95 % confidence level.

Keywords: Fluvoxamine maleate, differential pulse polarography, determination, tablets.

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